abstract：BACKGROUND:Some studies have shown that low dose of neuroleptic addition to ongoing antiobsessive treatment might be effective in treatment resistant obsessive-compulsive disorder (OCD). The primary purpose of this study was to evaluate the efficacy of low-dose quetiapine in clomipramine and serotonin reuptake inhibito...

journal_title：Journal of clinical psychopharmacology

authors： Sevincok L,Topuz A

更新日期：2003-10-01 00:00:00

abstract：:Some of the selective serotonin reuptake inhibitors (SSRI)-induced motor side effects are mediated by stimulating 5-HT2 receptors in the basal ganglia, probably because serotonin inhibits the subsequent neuronal dopamine release. We hypothesized that nefazodone, a serotonin 2 antagonist/reuptake inhibitor (SARI) that ...

journal_title：Journal of clinical psychopharmacology

authors： Avila A,Cardona X,Martin-Baranera M,Maho P,Sastre F,Bello J

更新日期：2003-10-01 00:00:00

abstract：:The selective serotonin reuptake inhibitor antidepressant fluoxetine inhibits alprazolam metabolism in vivo by inhibition of the cytochrome P450 3A4 enzyme. Citalopram is a selective serotonin reuptake inhibitor antidepressant that has not yet been fully evaluated with respect to its potential for cytochrome P450 3A4-...

journal_title：Journal of clinical psychopharmacology

authors： Hall J,Naranjo CA,Sproule BA,Herrmann N

更新日期：2003-08-01 00:00:00

abstract：:We examined kinetic and dynamic factors to determine the pharmacological and behavioral safety and tolerability of low versus high doses of an opiate antagonist, naltrexone (50 mg/day vs. 100 mg/day), and acamprosate (2 g/day vs. 3 g/day), a functional N-methyl-D-aspartate receptor antagonist, both independently and c...

journal_title：Journal of clinical psychopharmacology

authors： Johnson BA,O'Malley SS,Ciraulo DA,Roache JD,Chambers RA,Sarid-Segal O,Couper D

更新日期：2003-06-01 00:00:00

abstract：:A growing number of anticonvulsant drugs are receiving attention as possible mood stabilizers. This attention is based mainly on the assumption that the antimanic efficacy of anticonvulsants makes them suitable as mood stabilizers. However, their antidepressant properties have received less scrutiny. In this review, c...

journal_title：Journal of clinical psychopharmacology

authors： Ernst CL,Goldberg JF

更新日期：2003-04-01 00:00:00

abstract：:In this 6-week, open-label trial, combat veterans meeting DSM-IV criteria for posttraumatic stress disorder (PTSD) were treated with the atypical antipsychotic quetiapine. The starting dose was 25 mg at bedtime with subsequent titration based on tolerability and clinical response. Primary outcome was measured using th...

journal_title：Journal of clinical psychopharmacology

authors： Hamner MB,Deitsch SE,Brodrick PS,Ulmer HG,Lorberbaum JP

更新日期：2003-02-01 00:00:00

abstract：:Lithium augmentation, the most studied augmentation strategy for depression, has not been evaluated in patients with a history of non-response to multiple antidepressants. The objective of this study was to assess the efficacy of lithium augmentation for patients with a history of treatment resistant depression who al...

journal_title：Journal of clinical psychopharmacology

authors： Nierenberg AA,Papakostas GI,Petersen T,Montoya HD,Worthington JJ,Tedlow J,Alpert JE,Fava M

更新日期：2003-02-01 00:00:00

abstract：:Lithium alone or in combination with other psychotherapeutic drugs has long been the gold standard of management for bipolar disorder (BD). Recognition of its limitations in the acute and chronic management of BD has led to the development of alternative therapies. One such approach involves the use of antiepileptic d...

journal_title：Journal of clinical psychopharmacology

authors： Suppes T

更新日期：2002-12-01 00:00:00

abstract：:Patients with major depressive disorder remain at risk for relapse following remission and often continue to experience subthreshold symptoms. This study compared the rate of relapse of major depressive disorder and the prevalence of residual depressive symptoms during the continuation phase for patients treated with ...

journal_title：Journal of clinical psychopharmacology

authors： Perlis RH,Nierenberg AA,Alpert JE,Pava J,Matthews JD,Buchin J,Sickinger AH,Fava M

更新日期：2002-10-01 00:00:00

abstract：:Using the Karolinska Scales of Personality (KSP), we investigated the effect of the selective serotonin reuptake inhibitor citalopram on personality traits and the relationship between personality traits and peripheral indexes for central serotonergic function in patients with panic disorder at baseline and after 6 mo...

journal_title：Journal of clinical psychopharmacology

authors： Neuger J,Wistedt B,Aberg-Wistedt A,Stain-Malmgren R

更新日期：2002-08-01 00:00:00

abstract：:It has been suggested that maintenance treatment of patients who have remitted panic disorder with agoraphobia beyond the six months of acute phase imipramine treatment may decrease the risk of relapse. This study further explores the relationship between relapse and duration of imipramine treatment in this population...

journal_title：Journal of clinical psychopharmacology

authors： Mavissakalian MR,Perel JM

更新日期：2002-06-01 00:00:00

abstract：:In a recent study, the authors suggested that tachycardia, dry mouth, and sweating continued to burden patients with panic disorder with agoraphobia who have shown marked and stable response to 6 months of imipramine treatment at the fixed, weight-adjusted dose of 2.25 mg/kg/day. Although sexual dysfunction and weight...

journal_title：Journal of clinical psychopharmacology

authors： Mavissakalian M,Perel J,Guo S

更新日期：2002-04-01 00:00:00

abstract：:A role for serotonin in season affective disorder (SAD) has been explored with a variety of serotonergic pharmacologic agents. The authors initially hypothesized that metergoline, a nonspecific serotonin antagonist, would exacerbate depressive symptoms. In a small, open-label pilot study, the authors observed the oppo...

journal_title：Journal of clinical psychopharmacology

authors： Turner EH,Schwartz PJ,Lowe CH,Nawab SS,Feldman-Naim S,Drake CL,Myers FS,Barnett RL,Rosenthal NE

更新日期：2002-04-01 00:00:00

abstract：:A double-blind, placebo-controlled trial was performed to determine the efficacy and tolerability of 8 weeks of treatment with risperidone in the management of 48 adolescent and adult patients with Tourette syndrome. Twenty-four patients were randomly assigned to treatment with risperidone in doses of 0.5 to 6.0 mg/da...

journal_title：Journal of clinical psychopharmacology

authors： Dion Y,Annable L,Sandor P,Chouinard G

更新日期：2002-02-01 00:00:00

abstract：:In this study, the authors investigated the relationship between the metabolism of clomipramine (C) and the genotypes of cytochrome P450 (CYP) CYP2C19 and CYP2D6. Fifty-one Japanese patients (18 men and 33 women) were administered 10 to 250 mg/day of C by mouth and maintained on the same daily dose of C for at least 2...

journal_title：Journal of clinical psychopharmacology

authors： Yokono A,Morita S,Someya T,Hirokane G,Okawa M,Shimoda K

更新日期：2001-12-01 00:00:00

abstract：:The objective of this study was to investigate the efficacy of pirenzepine in the treatment of clozapine-induced hypersalivation. Pirenzepine is reported to counteract hypersalivation by its selective antagonistic activity on the M4-muscarinic receptor, which is stimulated by clozapine. Twenty patients with clozapine-...

journal_title：Journal of clinical psychopharmacology

authors： Bai YM,Lin CC,Chen JY,Liu WC

更新日期：2001-12-01 00:00:00

abstract：:The aim of this study was to estimate the long-term effectiveness of olanzapine as adjunctive therapy in patients with bipolar disorder who exhibited an inadequate response to mood stabilizers. Twenty-three Research Diagnostic Criteria (RDC) patients with bipolar I and II were assessed by means of the Schedule for Aff...

journal_title：Journal of clinical psychopharmacology

authors： Vieta E,Reinares M,Corbella B,Benabarre A,Gilaberte I,Colom F,Martínez-Arán A,Gastó C,Tohen M

更新日期：2001-10-01 00:00:00

abstract：:Newer atypical antipsychotics demonstrate superior effectiveness, with a diminished incidence of extrapyramidal side effects compared with older typical antipsychotics, but they have been associated with the development of obesity and new-onset diabetes. A small number of reports documenting modest hypertriglyceridemi...

journal_title：Journal of clinical psychopharmacology

authors： Meyer JM

更新日期：2001-08-01 00:00:00

abstract：:In this study, the authors examined the relationship between steady-state haloperidol blood levels and clinical response in patients with acute psychotic mania. Fifty-four inpatients with acute mania were randomly assigned to receive either haloperidol 25 mg/day or haloperidol 5 mg/day. Each subject also received a co...

journal_title：Journal of clinical psychopharmacology

authors： Chou JC,Czobor P,Dacpano G,Richardson N,Tuma I,Trujillo M,Cooper TB,Volavka J

更新日期：2001-08-01 00:00:00

abstract：:The reinforcing effects of methylphenidate (20-40 mg), d-amphetamine (10-20 mg), and placebo were assessed in eight healthy, non-sleep-deprived, non-drug-abusing outpatient volunteers. A modified progressive-ratio schedule was used to assess drug reinforcement in which a sampling session always preceded a self-adminis...

journal_title：Journal of clinical psychopharmacology

authors： Rush CR,Essman WD,Simpson CA,Baker RW

更新日期：2001-06-01 00:00:00

abstract：:Clinical studies that have evaluated serotonergic medications to reduce alcohol consumption have yielded conflicting results. These studies primarily treated patients with alcohol dependence, excluding those with a current depressive disorder, in an effort to differentiate any medication effects directly on drinking f...

journal_title：Journal of clinical psychopharmacology

authors： Pettinati HM,Volpicelli JR,Luck G,Kranzler HR,Rukstalis MR,Cnaan A

更新日期：2001-04-01 00:00:00

abstract：:The objective of this study was to compare the efficacy of the alpha-2a agonist guanfacine with that of dextroamphetamine for the treatment of adult attention-deficit/hyperactivity disorder (ADHD). Seventeen adult outpatients who met DSM-IV criteria for ADHD participated in a double-blind, placebo-controlled, crossove...

journal_title：Journal of clinical psychopharmacology

authors： Taylor FB,Russo J

更新日期：2001-04-01 00:00:00

abstract：:The long-term use of the serotonin-releaser and uptake-inhibitor 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") has been associated with memory impairments and increased liability to depressive mood and anxiety attacks. It is unclear, however, whether these psychologic deviations are reflected in alterations of t...

journal_title：Journal of clinical psychopharmacology

authors： Gamma A,Buck A,Berthold T,Vollenweider FX

更新日期：2001-02-01 00:00:00

abstract：:Remifentanil is a short-acting, esterase-metabolized opioid analgesic. This study compared the abuse liability of remifentanil with that of fentanyl and placebo in a randomized, double-blind, crossover study. Twelve recreational users of opioids received increasing doses of remifentanil (0.6, 1.2, 1.8, 2.4, and 3.0 mi...

journal_title：Journal of clinical psychopharmacology

authors： Baylon GJ,Kaplan HL,Somer G,Busto UE,Sellers EM

更新日期：2000-12-01 00:00:00

abstract：:Unlike many other areas of medicine, psychiatric clinical trials have no gold standard laboratory tests with which to measure drug effects. Although reliable and valid psychometric measures are available, the standard analysis of such measures obscures the clinical relevance of drug effects. In this study, the authors...

journal_title：Journal of clinical psychopharmacology

authors： Faraone SV,Biederman J,Spencer TJ,Wilens TE

更新日期：2000-12-01 00:00:00

abstract：:In a recent study, the authors gauged the net effectiveness of imipramine to be 53%; that is, of 110 patients having panic disorder with agoraphobia who started a course of imipramine at a fixed, targeted, weight-adjusted dose of 2.25 mg x kg(-1) x day(-1), 59 adhered to the regimen and showed a marked and stable resp...

journal_title：Journal of clinical psychopharmacology

authors： Mavissakalian MR,Perel JM

更新日期：2000-10-01 00:00:00

abstract：:The therapeutic spectrum of nemonapride, a new substituted benzamide, and its relationship with plasma concentrations of the drug and prolactin were investigated by a fixed-dose study (18 mg/day for 3 weeks) in 31 patients with acutely exacerbated schizophrenia. Of 31 patients, 25 (80.6%) were responders who showed a ...

journal_title：Journal of clinical psychopharmacology

authors： Kondo T,Mihara K,Yasui N,Nagashima U,Ono S,Kaneko S,Ohkubo T,Osanai T,Sugawara K,Otani K

更新日期：2000-08-01 00:00:00

abstract：:A randomized, double-blind, placebo-controlled study was conducted to assess the efficacy of risperidone in the treatment of developmental stuttering in 16 adults. Eight subjects received placebo and eight received risperidone at 0.5 mg once daily at night, increased to a maximum of 2 mg/day. After 6 weeks of treatmen...

journal_title：Journal of clinical psychopharmacology

authors： Maguire GA,Riley GD,Franklin DL,Gottschalk LA

更新日期：2000-08-01 00:00:00

abstract：:Twenty-four healthy male and female subjects, who participated in this randomized, double-blind, crossover study, received single nighttime doses of zaleplon 10 mg (therapeutic dose), zaleplon 20 mg, zolpidem 10 mg (therapeutic dose), zolpidem 20 mg, triazolam 0.25 mg (positive control), and placebo. Subjective behavi...

journal_title：Journal of clinical psychopharmacology

authors： Troy SM,Lucki I,Unruh MA,Cevallos WH,Leister CA,Martin PT,Furlan PM,Mangano R

更新日期：2000-06-01 00:00:00

abstract：:This study investigated the effects of antidepressant treatment on platelet activation in depressed patients with ischemic heart disease (IHD). Plasma levels of platelet alpha-granule release products beta-thromboglobulin (BTG) and platelet factor 4 (PF4) were measured in 17 depressed patients with IHD who were treate...

journal_title：Journal of clinical psychopharmacology

authors： Pollock BG,Laghrissi-Thode F,Wagner WR

更新日期：2000-04-01 00:00:00

abstract：:In an open clinical trial, serum concentrations of haloperidol pyridinium (C(HP+)) and reduced haloperidol pyridinium (C(RHP+)), as well as haloperidol (CH) and reduced haloperidol (C(RH)), were measured in 57 schizophrenic and schizoaffective inpatients during 6 weeks of short-term treatment. Psychopathology was moni...

journal_title：Journal of clinical psychopharmacology

authors： Ulrich S,Neuhof S,Braun V,Danos P,Pester U,Hoy L

更新日期：2000-04-01 00:00:00

abstract：:Two experiments examined the effects of methylphenidate in male and female patients enrolled in an outpatient treatment program for primary cocaine dependence. The first study was a component of a double-blind efficacy trial wherein 57 patients were first tested in a human laboratory for their initial responsiveness t...

journal_title：Journal of clinical psychopharmacology

authors： Roache JD,Grabowski J,Schmitz JM,Creson DL,Rhoades HM

更新日期：2000-02-01 00:00:00

abstract：:Successful discontinuation of therapeutic drugs requires patients to negotiate two potentially difficult phases. First, they must complete the drug discontinuation procedure itself, which may entail coping with rebound and withdrawal symptoms as well as anxiety due to stopping a treatment on which they depend psycholo...

journal_title：Journal of clinical psychopharmacology

authors： Spiegel DA

更新日期：1999-12-01 00:00:00

abstract：:The aim of this study was to compare the disposition of the tricyclic antidepressant clomipramine (C) in Japanese and Swedish patients receiving continuous treatment. Therapeutic drug monitoring data for C and the active metabolite N-desmethylclomipramine (DC) in Japanese patients receiving monotherapy (N = 12) and in...

journal_title：Journal of clinical psychopharmacology

authors： Shimoda K,Jerling M,Böttiger Y,Yasuda S,Morita S,Bertilsson L

更新日期：1999-10-01 00:00:00

abstract：:Tolcapone is a catechol-O-methyltransferase (COMT) inhibitor that has shown efficacy in the treatment of Parkinson's disease. The authors undertook the first study on the efficacy of this COMT inhibitor in the treatment of major depressive disorder (MDD). The authors also wanted to assess the effects of tolcapone on t...

journal_title：Journal of clinical psychopharmacology

authors： Fava M,Rosenbaum JF,Kolsky AR,Alpert JE,Nierenberg AA,Spillmann M,Moore C,Renshaw P,Bottiglieri T,Moroz G,Magni G

更新日期：1999-08-01 00:00:00

abstract：:Forty bipolar depressed inpatients underwent three consecutive cycles of total sleep deprivation (TSD). At the beginning of the study, 20 patients were free of psychotropic drugs and 20 had been receiving lithium medication for at least 6 months. Mood was rated on the Hamilton Rating Scale for Depression before and af...

journal_title：Journal of clinical psychopharmacology

authors： Benedetti F,Colombo C,Barbini B,Campori E,Smeraldi E

更新日期：1999-06-01 00:00:00

abstract：:The aims of this study were to examine whether pindolol, a serotonin (5-hydroxytryptamine [5-HT])-1A receptor antagonist, and mianserin, a 5-HT2A/C and alpha2-adrenoceptor (alpha2-AR) antagonist, may augment the clinical efficacy of fluoxetine, a selective serotonin reuptake inhibitor, and shorten the latency of onset...

journal_title：Journal of clinical psychopharmacology

authors： Maes M,Libbrecht I,van Hunsel F,Campens D,Meltzer HY

更新日期：1999-04-01 00:00:00

abstract：:Disturbed sleep is common in the elderly and is characterized by disordered sleep architecture with reduced time spent in slow wave sleep (SWS) and in rapid eye movement (REM) sleep. At present, no treatments are available to fully compensate for these disorders. In the elderly, vasopressin content is decreased at var...

journal_title：Journal of clinical psychopharmacology

authors： Perras B,Pannenborg H,Marshall L,Pietrowsky R,Born J,Lorenz Fehm H

更新日期：1999-02-01 00:00:00

abstract：:The objective of this study was to assemble expert clinical experience and judgment regarding the treatment of panic disorder in a systematic, quantitative manner, particularly with respect to changes during the past 5 years. A panel of 73 internationally recognized experts in the field of pharmacotherapy of anxiety a...

journal_title：Journal of clinical psychopharmacology

authors： Uhlenhuth EH,Balter MB,Ban TA,Yang K

更新日期：1998-12-01 00:00:00

abstract：:The pharmacokinetic parameters of clozapine and its two main metabolites, N-desmethylclozapine (norclozapine, active metabolite) and clozapine N-oxide, were evaluated, after oral administration, in 19 patients with chronic schizophrenia. Plasma and red blood cell (RBC) drug concentrations were determined by high-perfo...

journal_title：Journal of clinical psychopharmacology

authors： Guitton C,Abbar M,Kinowski JM,Chabrand P,Bressolle F

更新日期：1998-12-01 00:00:00